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Le limitazioni attuali della ricerca includono l'assenza di studi clinici randomizzati su larga scala nell'uomo, una comprensione ancora parziale dei meccanismi molecolari precisi e la mancanza di dati farmacocinetici dettagliati nell'uomo

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Given that the Phase I clinical trial in IPF demonstrated a reduction of senescent cells and SASP within eleven days after a single treatment of D+Q, and improvements in physiological outcomes after 10 weeks (105), we reasoned that a three-month period would provide important feasibility, compliance and efficacy data, as well as potentially reveal other cognitive and biomarker effects useful for designing a larger study